Exploring Potential Noninvasive Biomarkers in Eosinophilic Esophagitis in Children
نویسندگان
چکیده
منابع مشابه
Eosinophilic esophagitis in children and adults.
Adults and children with eosinophilic esophagitis (EoE) have distinct clinical and endoscopic presentations. Recognition of clinical signs, along with laboratory and endoscopic findings, is critical for the identification of patients with EoE because delay in diagnosis has been associated with esophageal remodeling and stricture formation. Clinical presentation varies considerably between adult...
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BACKGROUND Eosinophilic esophagitis (EoE) is of growing interest for pediatricians and allergists. There is no general agreement about diagnostic and clinical management procedures. The objective of this prospective, observational study was to evaluate the efficacy of a protocol for the etiologic diagnosis and accurate treatment of EoE in the pediatric population. PATIENTS AND METHODS Startin...
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Eosinophilic esophagitis (EoE) diagnosis and follow-up response to therapy is based on repeated endoscopies and histological examination for eosinophils/HPF. The procedure is invasive and risky in particular for the pediatric population. Presently, there is no highly sensitive and specific noninvasive blood test available to monitor the disease pathogenesis. Reports indicate the expression of P...
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intermittent solid food dysphagia and blockage was admitted because of chest pain, pyrosis, and fever (38.3 8C). The only medication she was on at the time of our evaluation was the inhaler Salbuta− mol−sulfate, which she used as needed. Symptoms started a few hours after a food blockage episode. Physical examina− tion was normal, except for tachycardia (135 bpm). Laboratory results showed: leu...
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A 74-year-old male with a history of dysphagia for 3 years presented with acute food impaction. Endoscopy showed a tight distal stricture with course rings at the middle third of the esophagus. Biopsies taken from the middle third of the esophagus showed marked infiltration of the intraepithelial lymphocytes mainly in a peripapillary distribution. The immunostains showed presence of CD3 and CD5...
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ژورنال
عنوان ژورنال: PEDIATRICS
سال: 2012
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2012-2183z